RNA structure is intimately related to function, yet methods to identify base-paired RNA strands in a transcriptome-wide manner in cells have remained elusive. One recent paper in Cell and two in Molecular Cell describe related methods to identify RNA sequences that interact in living cells, setting the stage for break-throughs in our understanding of RNA structure and function. Just like proteins, RNA molecules adopt 3D structures that are important for their processing and function. In fact, nearly all textbooks depict messenger RNAs as linear, non-structured, single-stranded molecules. Not only do most RNAs likely have specific 3D structures, but these structures are almost certainly important for the functions of these RNAs. Over the past several decades, a large toolbox of diverse methods has been developed to characterize RNA secondary structures and identify RNA sequences that base-pair with one another, whether in cis or in trans. These include computational modeling, phylogenetic analysis, genetic testing, and biochemical probing reviewed in Wan et al.

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The first big and quite surprising change was that Valve got rid of Solo queue in its original form. That said, Dota is a team game, so pushing players towards playing in pre-made parties to fully enjoy the game makes a lot of sense. This might currently be a problem because the new matchmaking update makes Solo a bit less enjoyable especially on the higher MMR brackets while finding a dedicated same-skill-level party is hard.

Maybe the next logical step would be to integrate a friend-finder in the client finding people close to your skill level, play-time preference, role preference, language, etc. So, to make the overall experience better for everyone it makes sense to incentivize players to behave more heavily. They are currently employing the stick method with the low behavior score ban waves, but a carrot could also be implemented:.

For example, maintaining a behavior score above 9k can give you periodic rewards like a free Rylai Wheel spin every month or something along those lines. All of this is aimed at making the support role more enjoyable to make it possible to own and visibly decide games from a support position. Because of this, we definitely expect this trend to continue.

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